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hepatology 4 (2), 131142

Excessive ROS production leads to apoptosis (Schieber and Chandel 2014)

Indeed, the combined application of BPC-157 and TB-500 is an area of growing interest, suggesting a synergistic approach to advanced regenerative medicine

As TP53 mutations are strong drivers of negative outcomes in multiple hematologic malignancies, as exemplified by relapsed pediatric acute lymphoblastic leukemia, APR-246 may likely have more broad clinical implications including synergy with traditional cytotoxic agents, as has been recently described.20 Together, shedding light on the synergistic mechanisms underlying APR-246 and azacitidine therapy as presented in this study are critical to continue to advance this novel therapeutic option for patients with the poorest outcomes to traditional treatments